Potential erroneous assignment of nonlinear data to the classical linear two-compartment open model

✍ Scribed by Anthony R. Disanto; John G. Wagner

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 389 KB
• Volume: 61
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600610411

✦ Synopsis

The classical two-compartment open model implies that if the dose is progressively raised the amount of drug transferred to tissue is directly proportional to dose. A nonlinear model considered in this report assumes that the amount of drug transferred to tissue is a curvilinear function of dose due to a limited capacity of the tissue to bind drug. Simulated (CJ) data, generated from the nonlinear equation appropriate t o the model, were found to be fit perfectly or almost perfectly to a double-exponential equation. The usual interpretation would lead to assignment of the classical two-compartment open model. The data reported emphasize the concept that with the limitations of assay sensitivity, several different doses of a drug need to be administered intravenously t o elaborate the appropriate pharrnacokinetic model. Kegphrases 0 Model, open, classical linear two compartmentequations relative to erroneous assignment of nonlinear data 0 Pharmacokinetic models-erroneous assignment of nonlinear data to classical linear two-compartment open model, equations 0 Drug transfer-linear two-compartment open model, erroneous assignment of nonlinear data