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Potential criteria for cohort selection in chemoprevention trials of uterine adenocarcinoma

✍ Scribed by Vicki V. Baker

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
444 KB
Volume
59
Category
Article
ISSN
0730-2312

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✦ Synopsis

Women at risk of uterine cancer include those with one or more of the following characteristics: obesity, nulliparity, late menopause, diabetes mellitus, prolonged unopposed estrogen use, and tamoxifen therapy. Risk is additionally increased by the presence of endometrial hyperplasia. The incorporation of biomarkers into the selection criteria of cohort groups at risk for developing endometrial cancer offers an innovative approach to the clinical design of chemoprevention trials of endometrial adenocarcinoma. Biomarkers that may be useful in cohort selection include nuclear morphometry, specific genetic abnormalities, and markers of Proliferation and differentiation.

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