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Potential clinical applications of siRNA technique: benefits and limitations

✍ Scribed by Shao-Hua Chen; Getu Zhaori


Book ID
108714068
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
111 KB
Volume
41
Category
Article
ISSN
0014-2972

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Gene therapy is a promising tool for the treatment of human diseases that cannot be cured by rational therapies. The major limitation for the use of small interfering RNA (siRNA), both in vitro and in vivo, is the inability of naked siRNA to passively diffuse through cellular membranes due to the st