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Potential carcinogenicity of Aza-aromatic hydrocarbons: Azabenz(A)anthracenes

✍ Scribed by R. M. Miao; M. J. Tanga; W. A. Suk; A. Miller; E. J. Reist

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
819 KB
Volume
37
Category
Article
ISSN
0020-7136

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✦ Synopsis

The potential carcinogenicity of 3 azabenz(a)anthracenes was determined in vitro. The 3 compounds tested were 1-, 2-, and 9-azabenz(a)anthracene. The initial assay was chemical carcinogen-induced enhancement of anchorage-independent survival of Rauscher leukemia virus-infected Fischer rat embryo cells, 2FR(4)50 (2FR4). Cells treated with 2- and 9-azabenz(a)anthracene showed dose-dependent increased survival. After continued subculturing, the surviving cells from 2- and 9-azabenz(a)anthracene-treated cultures displayed morphological transformation and ability to grow in semi-solid medium. Mock-treated controls and I-azabenz(a)anthracene-treated cultures did not show either of these properties. These data suggest that certain azabenz(a)anthracenes are potential carcinogens.

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