Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide and related compounds. A comparative study

Potential antipsychotic agents. Part 8.

Potential antipsychotic agents. Part 8. Antidopaminergic properties of a potent series of 5-substituted (−)-(S)-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,3-dimethoxybcnzaimides. Synthesis via common lithio intermediates

✍ Thomas Högberg; Peter Ström; Håkan Hall; Sven Ove Ögren 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 German ⚖ 583 KB

A series of 5-substituted (-)-(S)-N-[( l-ethylpyrrolidin-2-yl)methyl]-2,3-dimethoxybenzamides were made by reaction of the corresponding benzoyl chlorides with (S)-l-ethylpyrrolidine-2-methylamine (+ 14-16, 18-21). The acids required were prepared in a regiospecific manner from 5-bromo-2,3-dimethoxy