Potential antimitotic agents. Synthesis of some ethyl benzopyrazin-7-ylcarbamates, ethyl pyrido[3,4-b]pyrazin-7-ylcarbamates, and ethyl pyrido[3,4-e]-as-triazin-7-ylcarbamates

Synthesis of [3H]CI-980, ethyl[5-anino-1

Synthesis of [3H]CI-980, ethyl[5-anino-1,2-dihydro-2(S)-methyl-3(3-[3H]phenyl)pyrido[3,4-b]jpyrazin-7-YL] carbamate isethionate salt, a tubulin-binding, antimitotic, broad-spectrum antitumor agent

✍ Helen T. Lee; Peter W. K. Woo 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 226 KB

## Abstract [^3^H]CI‐980 (10b) was synthesized in an eight‐step sequence with an overall yield of 2.4%. Reaction of __m__‐bromophenyl lithium (2) with __N__‐ethoxycarbonyl‐L‐alanine gave the chiral ketone 3. Reduction of 3 with sodium borohydride followed by alkaline __N__‐deprotection and condensa