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Potential antileprotic agents. 3. Inhibition of mycobacterial dihydrofolic reductase by 2,4-diamino-5-methyl-6-alkylquinazolines

✍ Scribed by DeGraw, J. I.; Brown, V. H.; Colwell, W. T.; Morrison, N. E.


Book ID
127188481
Publisher
American Chemical Society
Year
1974
Tongue
English
Weight
404 KB
Volume
17
Category
Article
ISSN
0022-2623

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Nine novel nonclassical 2,4-diamino-6-methyl-5-thioarylsubstituted-7H-pyrrolo [2,3-d]pyrimidines 2-10 were synthesized as potential inhibitors of dihydrofolate reductase and as antitumor agents. The analogues contain various electron donating and electron withdrawing substituents on the phenylsulfan