Design, synthesis and biological evaluat
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Aleem Gangjee; Hiteshkumar D. Jain; Sherry F. Queener
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Article
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2005
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Journal of Heterocyclic Chemistry
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English
β 75 KB
Nine novel nonclassical 2,4-diamino-6-methyl-5-thioarylsubstituted-7H-pyrrolo [2,3-d]pyrimidines 2-10 were synthesized as potential inhibitors of dihydrofolate reductase and as antitumor agents. The analogues contain various electron donating and electron withdrawing substituents on the phenylsulfan