Potent hypolipidemic activity of mimetic amides of fibrates based on the 2-methoxy-4-(2-propenyl)phenoxyacetic scaffold

Discovery of potent and selective histam

Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold

✍ H.G.F. Richter; C. Freichel; J. Huwyler; T. Nakagawa; M. Nettekoven; J.-M. Planc 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 453 KB

A novel series of potent histamine H(3) receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold has been discovered. Several compounds display high selectivity over other histamine receptor subtypes and have favorable physicochemical properties, low potential for CY