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Potent and Selective Inhibitors of Breast Cancer Resistance Protein (ABCG2) Derived from the p -Glycoprotein (ABCB1) Modulator Tariquidar

✍ Scribed by Kühnle, Matthias; Egger, Michael; Müller, Christine; Mahringer, Anne; Bernhardt, Günther; Fricker, Gert; König, Burkhard; Buschauer, Armin


Book ID
120482634
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
192 KB
Volume
52
Category
Article
ISSN
0022-2623

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## Abstract Sunitinib is an orally active, multitargeted tyrosine kinase inhibitor which has been used for the treatment of metastatic renal cell carcinoma and imatinib‐resistant gastrointestinal stromal tumors. We aimed to investigate the __in vivo__ roles of the ATP‐binding cassette drug efflux t