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Potency of Individual Bile Acids to Regulate Bile Acid Synthesis and Transport Genes in Primary Human Hepatocyte Cultures

✍ Scribed by Liu, J.; Lu, H.; Lu, Y.-F.; Lei, X.; Cui, J. Y.; Ellis, E.; Strom, S. C.; Klaassen, C. D.


Book ID
126451655
Publisher
Oxford University Press
Year
2014
Tongue
English
Weight
411 KB
Volume
141
Category
Article
ISSN
1096-6080

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Primary human hepatocytes were used to elucidate the effect of individual bile acids on bile acid formation in human liver. Hepatocytes were treated with free as well as glycine-conjugated bile acids. Bile acid formation and messenger RNA (mRNA) levels of key enzymes and the nuclear receptor short h