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Posttranslational phosphorylation of mutant p53 protein in tumor development

✍ Scribed by Manabu Matsumoto; Mutsuo Furihata; Yuji Ohtsuki

Book ID: 106238953
Publisher: Springer
Year: 2006
Tongue: English
Weight: 479 KB
Volume: 39
Category: Article
ISSN: 0918-4287
DOI: 10.1007/s00795-006-0320-0

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## Background: The p53 tumor suppressor gene encodes a nuclear phosphoprotein that is thought to be important to cell cycle regulation and dna repair and that also may regulate induction of apoptosis by ionizing radiation. somatic p53 gene mutations occur in 30-50% of breast carcinomas and are asso