Posttranscriptional regulation of the expression of CAD gene during differentiation of F9 teratocarcinoma cells by induction with retinoic acid and dibutyryl cyclic AMP
β Scribed by Gadiparthi N. Rao; Robert L. Church; Jeffrey N. Davidson
- Book ID
- 115920563
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 586 KB
- Volume
- 232
- Category
- Article
- ISSN
- 0014-5793
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Several differentiation-specific genes, including those for collagen IV and laminin, are induced by retinoic acid IRA) in mouse F9 teratocarcinoma cells. Dibutyryl CAMP can enhance the effect of RA in these cells, but dibutyryl CAMP alone does not induce these genes. Inhibition of RNA synthesis with
## Abstract F9 embryonal carcinoma cells differentiate in response to retinoic acid (RA). To investigate the regulation of RA receptors (RARs) expression during this process, cDNA probes specific for the major RAR isoforms were used. In contrast to the level of RARΞ²2 mRNA which was high in cells tr