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Posttranscriptional Regulation of Mammalian Methionine Synthase by B12

✍ Scribed by Sumedha Gulati; Lawrence C. Brody; Ruma Banerjee

Book ID
115583801
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
98 KB
Volume
259
Category
Article
ISSN
0006-291X

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Thymidylate synthase (TS) is an essential enzyme that catalyzes the formation of thymidylic acid in the de novo biosynthetic pathway and i s the target enzyme for a variety of chemotherapeutic agents. The TS gene is expressed at a much higher level in proliferating cells than in quiescent cells. Con