Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence

Modulation of the expression of p16INK4a

Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: Implications for cellular senescence

✍ Deguang Zhu; Gang Xu; Shanaz Ghandhi; Karen Hubbard 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 193 KB

Cellular senescence is a terminal growth phase characteristic of normal human diploid fibroblasts. Altered gene expression during cellular senescence is numerous compared to that of younger proliferative cells in culture. We have previously reported that the levels and activities of hnRNP A1 and A2