𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Postthaw clotting of peripheral blood stem cell products due to insufficient anticoagulant

✍ Scribed by Ronit Reich-Slotky; Nita Patel; Shatrina Dael; Mildred Semidei-Pomales; Hannah Stephens; Michael Reich; Joseph Schwartz

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
95 KB
Volume
24
Category
Article
ISSN
0733-2459

No coin nor oath required. For personal study only.

✦ Synopsis

The amount of acid citrate dextrose formula A (ACD-A), which is a commonly used anticoagulant in leukopheresis, has to ensure both the safety of the donor and guarantee the integrity of the peripheral blood stem cell (PBSC) product until its transplant. Two recent consecutive cases of postthaw PBSC product clotting initiated a look-back investigation of the ACD-A percentage in leukopheresis products collected in our facility. The data indicated a significant difference between the average amount of ACD-A in prefreezing products collected during 2006 (11.4%) and in products collected during 2007 and 2008 (8.8% and 8.7%, respectively). These findings and the fact that the two clotted products had less than 7% ACD-A indicated that insufficient amount of anticoagulant might contribute to their clotting. This investigation prompted us to modify our collection and thawing procedures to prevent similar events in the future.

📜 SIMILAR VOLUMES

Peripheral blood stem cell recovery foll
Peripheral blood stem cell recovery following early termination of apheresis due to hypotension in a 4.8-kg infant
✍ Jessie Alex; Matthew J. Bahl; Annette J. Schlueter 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 55 KB

We report a case in which peripheral blood stem cells (PBSC) were successfully recovered following early termination of a collection procedure due to hypotension in a 7-month-old patient. The patient was diagnosed at 4 months of age with neuroblastoma stage IV-S with favorable Shimada histology. She