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Postsynthetic Generation of a Major Acrolein Adduct of 2‘-Deoxyguanosine in Oligomeric DNA †

✍ Scribed by Khullar, Sonia; Varaprasad, Chamakura V.; Johnson, Francis

Book ID
125929045
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
99 KB
Volume
42
Category
Article
ISSN
0022-2623

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Acrolein, a known mutagen, undergoes reaction in vitro under physiological conditions with both 2(')-deoxyguanosine and native DNA to give rise to exocyclic adducts of the 5,6,7,8-tetrahydropyrimido[1,2-a]purine-10(3H)-one class having an hydroxy group at either the 6 or the 8 position. Previously w