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Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease

✍ Scribed by Ardiles, A. O.; Tapia-Rojas, C. C.; Mandal, M.; Alexandre, F.; Kirkwood, A.; Inestrosa, N. C.; Palacios, A. G.


Book ID
117995016
Publisher
National Academy of Sciences
Year
2012
Tongue
English
Weight
901 KB
Volume
109
Category
Article
ISSN
0027-8424

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## Abstract Alzheimer's disease (AD) is the most common form of dementia and is pathologically characterized by senile plaques, neurofibrillary tangles, synaptic disruption and loss, and progressive neuronal deficits. The exact mechanism(s) of AD pathogenesis largely remain unknown. With advances i