Postproline cleaving enzyme: identification as serine protease using active site specific inhibitors

Mechanism-based isocoumarin inhibitors f

Mechanism-based isocoumarin inhibitors for serine proteases: Use of active site structure and substrate specificity in inhibitor design

✍ James C. Powers; Chih-Min Kam; Lakshmi Narasimhan; Joszef Oleksyszyn; Maria A. H 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 781 KB

Isocoumarins are potent mechanism-based heterocyclic irreversible inhibitors for a variety of serine proteases. Most serine proteases are inhibited by the general serine protease inhibitor 3,4-dichloroisocoumarin, whereas isocoumarins containing hydrophobic 7-acylamino groups are potent inhibitors f