Postoperative recovery of mitochondrial function of the human liver graft procured and preserved with University of Wisconsin (UW) solution

✍ Scribed by N. Osaki; B. Ringe; H. Bunzendahl; Y. Taki; G. Gubernatis; M. Oellerich; E.-R. Kuse; M. Burdelski; S. Uemoto; M. Kimoto; Y. Yamaoka; K. Ozawa; R. Pichlmayr

• Book ID: 104737502
• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 501 KB
• Volume: 3
• Category: Article
• ISSN: 0934-0874
• DOI: 10.1007/bf00355457

✦ Synopsis

Changes in arterial blood ketone body ratio (KBR) were investigated in 47 human liver transplantations. Of the 20 grafts preserved with University of Wisconsin (UW) solution, 10 had a cold preservation period of less than 10 h (UWS group) and 10 of more than 10 h (UWL group). In 27 other cases, grafts were preserved with EuroCollins (EC) solution for less than 10 h (EC group). In the EC group, KBR increased over 0.7 within 6 h after reperfusion of the graft in 17 cases (63%) and within 24 h in 7 cases (26%). In the 3 other cases, KBR failed to recover, and these patients underwent retransplantation. In the UW group, KBR recovered within 6 h in 13 cases (65%) and within 24 h in 7 cases (35%). There were no significant differences between the UWS and U W L groups. It is shown that the mitochondrial function of liver grafts preserved with UW solution can be well maintained even after extended preservation periods of more than 10 h.