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Postoperative radiotherapy and radiotherapy combined with CCNU chemotherapy for treatment of brain gliomas

✍ Scribed by Tomasz Trojanowski; Jerzy Pceszyński; Krzysztof Turowski; Stanisław Kamiński; Igor Gościński; Marian Reinfus; Tadeusz Krzyszkowski; Marek Pyrich; Adam Bielawski; Czesława Leszczyk; Barbara Bendarzewska; Andrzej Staszczak; Halina Koźniewska

Publisher
Springer US
Year
1988
Tongue
English
Weight
464 KB
Volume
6
Category
Article
ISSN
0167-594X

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✦ Synopsis

A prospective, randomized trial evaluates the effects of two postoperative treatment regimens on survival in 198 adult patients with supratentorial gliomas. All patients were irradiated with 6 000 rads after possibly radical removal of tumors. CCNU administration in the dosis of 100 mg/sq m of body surface every 6-8 weeks following surgery proved to have no significant effect on the survival of patients. The median survival time in patients receiving radiation therapy alone was 61 _+ 7 weeks, while in those receiving additional chemotherapy was 56 + 4 weeks. Tumor histological malignancy and patients age were found to be the only important prognostic factors, irrespective of the treatment modality.

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