𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Postoperative adjuvant immunotherapy of gastric cancer with BCG-cell wall skeleton

✍ Scribed by Takenori Ochiai; Hiroshi Sato; Ryoichi Hayashi; Takehide Asano; Hirotoshi Sato; Yuichi Yamamura

Publisher
Springer-Verlag
Year
1983
Tongue
English
Weight
386 KB
Volume
14
Category
Article
ISSN
0340-7004

No coin nor oath required. For personal study only.

✦ Synopsis

The clinical effectiveness of immunotherapy with the cell wall skeleton of Bacillus Calmette-GuΓ©rin was assessed in a study involving 140 consecutive patients with gastric cancer, who were gastrectomized at a single institution from January 1976 through December 1978. These patients were randomized by an envelope method after operation and divided into three treatment groups: 'control', 'chemotherapy', and 'chemotherapy plus immunotherapy with BCG-CWS.' Only two patients who died during surgery were excluded, and a survey of survival periods was made on the remaining 138 patients in January 1982. As a result, statistically significant differences in the survival rate curve were observed between the control and chemotherapy plus immunotherapy groups (P less than 0.01), and between the chemotherapy and chemotherapy plus immunotherapy groups (P less than 0.05). These results emphasize effectiveness of BCG-CWS as an adjuvant immunotherapeutic agent in gastrectomized cancer patients.

πŸ“œ SIMILAR VOLUMES

Phase I–II study of intratumor immunothe
Phase I–II study of intratumor immunotherapy with BCG cell wall skeleton plus P3
✍ S. P. Richman; J. U. Gutterman; E. M. Hersh; E. E. Ribi πŸ“‚ Article πŸ“… 1978 πŸ› Springer-Verlag 🌐 English βš– 335 KB

A vaccine composed of BCG cell wall skeleton (CWS) and a trehalose dimycolate called P3, attached to microdroplets of mineral oil, was evaluated for activity and toxicity when injected into tumor nodules. A total of 99 nodules in 23 patients with metastatic melanoma and carcinoma of the breast were

Controlled clinical trial of adjuvant im
Controlled clinical trial of adjuvant immunotherapy with BCG and neuraminidase-treated autologous tumour cells in large bowel cancer
✍ B. N. Gray; C. Walker; L. Andrewartha; S. Freeman; R. C. Bennett πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 342 KB

A controlled, randomised clinical trial of immunotherapy was performed in 301 patients with stage B or C colorectal cancer. The immunotherapy treatment consisted of 18 vaccinations over a 2 year period following surgery with a combination of BCG given by scarification plus subcutaneous injection of

Randomized controlled study of postopera
Randomized controlled study of postoperative adjuvant immunochemotherapy withNocardia rubracell wall skeleton (N-CWS) and Tegafur for gastric carcinoma
✍ Shohei Koyama; Azusa Ozaki; Yoji Iwasaki; Takao Sakita; Toshiaki Osuga; Akira Wa πŸ“‚ Article πŸ“… 1986 πŸ› Springer-Verlag 🌐 English βš– 757 KB

These results emphasize the effectiveness of N-CWS as an adjuvant immunotherapeutic agent in postoperative gastric cancer patients. The main side effects of N-CWS were skin lesions in the injected sites and fever, but these were temporary and not serious.