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Postnatal morphine administration alters hippocampal development in rats

✍ Scribed by Christopher M. Traudt; Ivan Tkac; Kathleen M. Ennis; Leah M. Sutton; Daniel M. Mammel; Raghavendra Rao

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
766 KB
Volume
90
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Morphine is frequently used as an analgesic and sedative in preterm infants. Adult rats exposed to morphine have an altered hippocampal neurochemical profile and decreased neurogenesis in the dentate gyrus of the hippocampus. To evaluate whether neonatal rats are similarly affected, rat pups were injected twice daily with 2 mg/kg morphine or normal saline from postnatal days 3 to 7. On postnatal day 8, the hippocampal neurochemical profile was determined using in vivo ^1^H NMR spectroscopy. The mRNA and protein concentrations of specific analytes were measured in hippocampus, and cell division in dentate gyrus was assessed using bromodeoxyuridine. The concentrations of γ‐aminobutyric acid (GABA), taurine, and myo‐insotol were decreased, whereas concentrations of glutathione, phosphoethanolamine, and choline‐containing compounds were increased in morphine‐exposed rats relative to control rats. Morphine decreased glutamic acid decarboxylase enzyme levels and myelin basic protein mRNA expression in the hippocampus. Bromodeoxyuridine labeling in the dentate gyrus was decreased by 60–70% in morphine‐exposed rats. These results suggest that recurrent morphine administration during brain development alters hippocampal structure. © 2011 Wiley Periodicals, Inc.

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