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Postmarketing surveillance of the safety of cimetidine: 15-year mortality report

✍ Scribed by J. Beresford; D. G. Colin-Jones; A. C. Flind; M. J. S. Langman; D. H. Lawson; R. F. A. Logan; K. R. Paterson; M. P. Vessey

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 96 KB
Volume: 7
Category: Article
ISSN: 1053-8569
DOI: 10.1002/(sici)1099-1557(199809/10)7:5<319::aid-pds367>3.0.co;2-k

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✦ Synopsis

The pattern of mortality after 15 years of observation is reported among almost 10,000 patients who were taking cimetidine when they were ®rst recruited between 1977 and 1980. Many took the drug for a number of years, some switching to other antisecretory agents as the study progressed. The ®ndings are reassuring and provide no evidence of any long-term adverse eects of cimetidine which might be detected by monitoring mortality rates. The data have also been used to examine the possible positive relationships between aluminium ingestion and Alzheimer's disease and H. pylori infection and ischaemic heart disease. No signi®cant evidence was obtained in support of the existence of these relationships.

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