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Postincubation with aclarubicin reverses topoisomerase II mediated DNA cleavage, strand breaks, and cytotoxicity induced by VP-16

✍ Scribed by Lone Nørgård Petersen; Peter Buhl Jensen; Boe Sandahl Sørensen; Svend Aage Engelholm; Mogens Spang-Thomsen


Book ID
104985728
Publisher
Springer US
Year
1994
Tongue
English
Weight
926 KB
Volume
12
Category
Article
ISSN
0167-6997

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✍ Aurelio Lorico; Mauro Boiocchi; Germana Rappa; Soumitra Sen; Eugenio Erba; Mauri 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 619 KB

Pre-treatment with low, non-toxic concentrations ( 0 . 0 4 ~~) of methotrexate (MTX) for I6 hr increased etoposide (VP 16)induced growth inhibition and cytotoxicity in the U937 human histiocytic lymphoma cell line. VP I6 cytotoxicity was significantly potentiated when the drug was given for 2 hr imm