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For many years, chemotherapy has been utilized for the treatment of malignant brain tumors with minimal success. This particularly true with chemotherapy in adult malignant gliomas for which no new drug has been approved for use since the initial studies using nitrosoureas and procarbazine in the ea
Improvements in brain tumor therapy have paralleled advancements in brain tumor imaging. Thus, stereotactic surgery was enabled by computed tomography scanning and localized radiotherapy by studies that confirmed the relationship between radiologic images and the actual tumor location. The neuroonco
Objective: to investigate the role of the stem cell regulator NUMB, and the differential splicing of NUMB isoforms, in the growth of PNETs. Methods: We investigated the expression of NUMB mRNA in tumor samples and cell lines derived from neuroblastoma, Ewing sarcoma, and medulloblastoma, using RT-PC