Poster session 4: Neuroimaging, surgical therapy, transplantation
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 807 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
✦ Synopsis
data at 120 and 240 min after 123 I-MIBG injection. Regional MIBG uptake was determined on two Single Photon Emission Tomographies (SPECT) in 5 regions of the left ventricle.
Results: At 120 or 240 min, the mean H/M ratios were significantly different among the three groups (P Ͻ 0.0001). H/M ratios of both NDPD and DPD patients groups (H/M 240 ϭ 1.83 Ϯ 0.50 and 1.24 Ϯ 0.40 respectively) were significantly lower than in MSA patients (H/M 240 ϭ 2.52 Ϯ 0.60). However, in NDPD patients, H/M was significantly higher than in DPD patients. When compared to MSA patients, NDPD patients showed a regional reduction in MIBG uptake in all left ventricle regions markedly in the apex and the inferior wall.
Conclusions: Our results suggest that MIBG myocardial scintigraphy (analysis of both H/M ratio and regional MIBG uptake pattern) may be more sensitive than standard autonomic testing for the early detection of silent autonomic dysfunction in PD.