✦ LIBER ✦

Poster session 4, Abstracts 1279–1290

Book ID: 102503214
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 66 KB
Volume: 19
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.20185

No coin nor oath required. For personal study only.

✦ Synopsis

Objective: To analyse the effects of sub threshold 1 Hz repetitive transcranial magnetic stimulation (rTMS) of left motor and premotor cortex on objective tic ratings, using standardised video and audio ratings.

Background: In a previous study, sub threshold 1 Hz rTMS of left motor and premotor cortex failed to improve tics in patients with Gilles de la Tourette Syndrome (GTS) as determined by self-assessment scores. However, video ratings had not been analysed.

Methods: In a placebo-controlled cross-over study, the following sub threshold 1 Hz rTMS conditions (2,400 stimuli delivered on 2 consecutive days) were tested in 13 patients with GTS: left motor, left premotor and left motor sham stimulation. Before and immediately after each intervention, tics were recorded using a standardised video protocol. A blinded investigator rated the videos using the modified Rush videotape scale and a newly developed "Adapted Yale" Video Scale.

Results: Tics were partially, albeit non-significantly, suppressed following each of the three interventions. However, the effect of active rTMS did not exceed the effect observed following sham stimulation.

Conclusion: We conclude that low intensity 1 Hz left motor or premotor TMS is not a useful treatment for tics in GTS.

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