Poster display II

• Book ID: 104624429
• Publisher: Springer US
• Year: 1991
• Tongue: English
• Weight: 662 KB
• Volume: 5
• Category: Article
• ISSN: 0920-3206
• DOI: 10.1007/bf00055757

✦ Synopsis

The aorta is rather largely used as a model vessel for the analysis of vascular changes induced by hypertension or atherosclerosis.

In the present study we have analyzed the pharmacological characteristics and the autoradiographic localization of 3H-PN 200-110 (3H-PN) binding sites in sections of rat,rabbit and human aorta. PN 2OO-110 (Isradipine,Sandoz) is the only calcium entagonist available considered to be potentially useful for control of atNerogenesis with practical doses. This work looked at possible species differences in the pharmacological properties or in the localization of the compound in the aorta.

3H-PN was selectively hound to sections of rat,rabbit and human aorta in a manner consistent with the labeling of dihydropyridine-sensitive channels. Anatomically it was bound by smooth muscle of aortic lamellae with higher density in the adventitial side. No species differences were noticeable in the pharmacological profile or in the anatomical localization of 3H-PN in the aorta.

These findings suggest that rat and rabbit aorta could be a model to study the activity of calcium antagonists.