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Poster 282: Toxicity of Bupivacaine on Intervertebral Disk Cells

✍ Scribed by Gwendolyn A. Sowa; Paulo Coelho; James D. Kang; Ho Lee; Stephen M. O'Connell; Rebecca Studer; Gianluca Vadala; Nam V. Vo

Book ID: 119349145
Publisher: Wiley (John Wiley & Sons)
Year: 2009
Tongue: English
Weight: 44 KB
Volume: 1
Category: Article
ISSN: 1934-1482
DOI: 10.1016/j.pmrj.2009.08.304

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## Abstract Nucleus pulposus cells (NPCs) from degenerating disks produce catabolic and inflammatory factors, including interleukin (IL)‐1, nitric oxide (NO), prostaglandin E2 (PGE‐2), and matrix metalloproteinaes (MMPs). An imbalance between MMPs and tissue inhibitors of matrix metalloproteinases