Postchemotherapy residual masses in germ cell tumor patients : Content, clinical features, and prognosis

✍ Scribed by Sally P. Stenning; M. Constance Parkinson; Cyril Fisher; Graham M. Mead; Patricia A. Cook; Sophie D. Fossa; Alan Horwich; William G. Jones; Edward S. Newlands; R. Timothy Oliver; A. Elizabeth Stenwig; Peter M. Wilkinson

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 173 KB
• Volume: 83
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19981001)83:7<1409::aid-cncr19>3.0.co;2-8

✦ Synopsis

In a retrospective study that included a detailed histopathologic review, the clinicopathologic features of patients with germ cell tumors (GCT) and resectable residual masses after chemotherapy were assessed.

METHODS.

Histologic material from 153 patients was available for review. Recorded details included primary histologic diagnosis, location, size and number of metastases, marker levels before and after chemotherapy, and completeness of surgical excision. A median of seven histologic sections per resection were reviewed by two pathologists independently (and together when disagreement occurred). In each case, details were recorded regarding fibrosis, necrosis, hemorrhage, embryonal carcinoma (undifferentiated teratoma), yolk sac tumor, choriocarcinoma (trophoblastic tumor), differentiated teratoma (mature and immature), dysplasia in somatic tissues, and non-germ cell tumor (GCT) malignancies. The percentage of the sample that each of these components comprised was also estimated.