Post-exposure prophylaxis with a maraviroc-containing regimen after occupational exposure to a multi-resistant HIV-infected source person
✍ Scribed by Frédéric Méchai; Yann Quertainmont; Sabrinel Sahali; Jean-François Delfraissy; Jade Ghosn
- Book ID
- 102385694
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 67 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
Abstract
We report the case of a health care worker who received a post‐exposure prophylaxis including an investigational drug, maraviroc, after a needle stick percutaneous injury to an HIV‐infected patient with late‐stage disease and harboring a multi‐drug resistant virus. Post‐exposure prophylaxis including maraviroc was pursued for a total of 28 days, with a weekly clinical and biological evaluation. Post‐exposure prophylaxis was well tolerated, with no increase in liver function tests. The health care worker remained HIV‐negative after a 6‐month follow‐up. J. Med. Virol. 80:9–10, 2008. © 2007 Wiley‐Liss, Inc.