✦ LIBER ✦
POSSIBLE ROLE OF FAS ANTIGEN (CD 95) IN HUMAN AMNIOTIC EPITHELIAL CELL DEATH: AN IN VITRO STUDY
✍ Scribed by Sankar Surendran
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 80 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1065-6995
No coin nor oath required. For personal study only.
✦ Synopsis
Treatment of human amniotic epithelial (HAE) cells with anti‐Fas monoclonal antibody (CH 11) at 100ng/ml or 1μg/ml for 12 or 24h increased necrotic cell death. Apoptotic cell death induced by this antibody was significantly increased, although far fewer cells underwent apoptosis, as determined by the TUNEL method. This study suggests that Fas antigen is an important mediator in HAE cell death.