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Possible Role of Extracellular Signal-Regulated Kinase Pathway in Regulation of Sox9 mRNA Expression in Chondrocytes under Hydrostatic Pressure

✍ Scribed by Kensuke Mio; Jennifer Kirkham; William A. Bonass

Book ID
118729332
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
290 KB
Volume
104
Category
Article
ISSN
1389-1723

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## Abstract Transforming growth factor (TGF‐β1) is a potent inducer of chondrogenesis and stimulant of cartilage extracellular matrix (ECM) synthesis. Tissue inhibitor of metalloproteinases‐3 (TIMP‐3) is located in ECM and is the major inhibitor of matrix metalloproteinases (MMPs) and aggrecanase,