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Possible Role of Calpain in Normal Processing of β-Amyloid Precursor Protein in Human Platelets

✍ Scribed by Ming Chen; Jacques Durr; Hugo L. Fernandez

Book ID
115586004
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
156 KB
Volume
273
Category
Article
ISSN
0006-291X

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## Abstract Proteolytic processing of the amyloid precursor protein by β ‐and γ‐secretases results in the production of Alzheimer's disease (AD) Aβ amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve