## Abstract Glutathione SβTransferases (GSTs) are a family of phase II enzymes involved in the detoxification of potential carcinogens and provided of a strong antioxidant function by neutralizing electrophiles and free radicals. The __GSTM1__ and __GSTT1__ isoenzymes exhibit deletion polymorphisms
Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population
β Scribed by Leelakumari Sreeja; Vani Syamala; Sreedharan Hariharan; Jayaprakash Madhavan; Sivanandan Choondal Devan; Ravindran Ankathil
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 287 KB
- Volume
- 50
- Category
- Article
- ISSN
- 1435-232X
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## Abstract Genetic backgrounds may modify the association of environmental tobacco smoke (ETS) with lung cancer risk. Polymorphisms of both the activating and detoxifying enzymes, cytochrome P4501A1 (CYP1A1) and glutathioneβSβtransferase M1 (GSTM1), may be important as genetic factors. We conducte
## Abstract ## Background. The interβindividual differences in upper aerodigestive tract (UADT) cancer risk may be partly attributed to the polymorphic variability in the __CYP1A1__ gene that is involved in the metabolic activation of xenobiotics to carcinogenic reactive metabolites. ## Methods.