Possible regulation of soluble icam-1 levels by interleukin-1 in a sub-set of breast cysts

✍ Scribed by L. C. Lai; S. Kadory; C. Cornell; T. W. J. Lennard

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: French
• Weight: 386 KB
• Volume: 55
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910550412

✦ Synopsis

There are 2 main groups of breast cysts characterized by their intracystic sodium-to-potassium ratios. Women who have intracystic Na/K < 3 may have a higher risk of developing breast cancer than those who have intracystic Na/K > 3. The cell adhesion molecule, ICAM-I, has been shown to be inducible by interleukin-I (IL-I). Furthermore, ICAM-I may be involved in the progression of metastasis in certain malignancies. The aim of this study was to measure intracystic soluble ICAM-I (SICAM-I) and IL-l a/p levels and to assess the relationships between these substances. Wide-ranging concentrations of SICAM-I, ILla and IL-I p were found in breast-cyst fluid. The high-electrolyte-ratio group had intracystic levels of SICAM-I and IL-IP which were significantly higher than those of the low-electrolyte-ratio group. No significant difference was found between IL-lol concentrations in the 2 groups of breast cysts. Strong positive correlations were found between SICAM-I and ILla, SICAM-I and IL-I p, and IL-I (Y and IL-I p. The significance of the higher concentrations of SICAM-I in the high-electrolyteratio group remains to be determined, but the results of this study suggest that slCAM-I levels in the high-electrolyte-ratio group may be regulated in part by IL-I (Y and IL-I p.