Possible protein binding displacement interaction between glibenclamide and metolazone

✍ Scribed by S. George; A. McBurney; A. Cole

• Book ID: 104718753
• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 268 KB
• Volume: 38
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00314813

✦ Synopsis

The effects of metolazone on the protein binding of glibenclamide were studied. It was found that increasing metolazone concentrations up to 100 ng/ml had no significant effect on the protein binding of glibenclamide studied at 10 micrograms/ml. Metolazone is unlikely to cause a clinically significant increase in the free fraction of glibenclamide in patients receiving both drugs.