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Possible participation of a prostaglandin E1 analogue in the aggravation of diabetic nephropathy

✍ Scribed by Yuji Aoki; Yasutoshi Yanagisawa; Hisao Oguchi; Kunihiko Yazaki; Seiichi Furuta


Book ID
119135298
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
500 KB
Volume
16
Category
Article
ISSN
0168-8227

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The dehydration of the P-hydroxycyclopentanone, 11,16dihydroxy-16-methyl-9-oxo-13-trans-protenoic acid methyl ester, an analogue of prostaglandin El, proceeds with acid catalysis (pH < 3), by uncatalyzed routes (pH N 4 and N 7), and with base catalysis (pH N 5-6 and > 8). Deuterium from the solvent