Possible mediation of catecholaminergic pathways in the antinociceptive effect of an extract ofCannabis sativa L.

✍ Scribed by S. Ferri; E. Cavicchini; P. Romualdi; E. Speroni; G. Murari

• Book ID: 104716732
• Publisher: Springer
• Year: 1986
• Tongue: English
• Weight: 489 KB
• Volume: 89
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00310637

✦ Synopsis

An extract of cannabis (5 and 15 mg/kg expressed as delta 9-THC) orally administered to rats caused an elevation of the nociceptive threshold (tail-flick latency and vocalization tests). Naloxone and naltrexone (blockers of mu-type opiate receptors) as well as MR 1452 (blocker of kappa opiate receptors) did not prevent the antinociceptive effect of cannabis when used at the dose of 2 mg/kg SC; only a high dose (10 mg/kg SC) of these narcotic antagonists partially blocked cannabis antinociception. ICI 154, 129, an antagonist of delta-type opiate receptors, failed to prevent the cannabis-induced rise in nociceptive threshold when used at a dose of 2 mg/kg SC but produced a significant effect at 10 mg/kg SC. While the role of opiate receptors does not seem fundamental to cannabis antinociception, the clear-cut effectiveness shown by 6-hydroxydopamine (a neurotoxin which causes a degeneration of catecholamine-containing terminals) in reducing cannabis antinociception is indicative of a participation of catecholamines in the phenomenon.