Impaired differentiation of HPRT-deficie
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Jason Yeh; Shuang Zheng; Bruce D. Howard
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Article
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1998
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John Wiley and Sons
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English
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Lesch-Nyhan syndrome is a hereditary disorder of purine metabolism causing overproduction of uric acid and neurological problems including spasticity, choreoathetosis, mental retardation, and compulsive self-mutilation. The syndrome is caused by a defect in the enzyme hypoxanthine-guanine phosphorib