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Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis

โœ Scribed by Shoji Fukushima


Book ID
114070380
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
74 KB
Volume
477
Category
Article
ISSN
0027-5107

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Possible rare involvement of O6-methylgu
โœ Tianxin Chen; Shinji Yamamoto; Mitsuaki Kitano; Takashi Murai; Hideki Wanibuchi; ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 56 KB ๐Ÿ‘ 2 views

O6-methylguanine is known as one of the major premutagenic lesions in the human and rodent carcinogenesis process. O6-methylguanine-DNA methyltransferase (MGMT), which repairs methylated guanine bases, might prevent the G:C to A:T transition, and transgenic mice carrying this MGMT gene have been rep