Possible rare involvement of O6-methylgu
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Tianxin Chen; Shinji Yamamoto; Mitsuaki Kitano; Takashi Murai; Hideki Wanibuchi;
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Article
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1998
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John Wiley and Sons
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English
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๐ 2 views
O6-methylguanine is known as one of the major premutagenic lesions in the human and rodent carcinogenesis process. O6-methylguanine-DNA methyltransferase (MGMT), which repairs methylated guanine bases, might prevent the G:C to A:T transition, and transgenic mice carrying this MGMT gene have been rep