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Possible involvement of multiple cytochrome P450S in fentanyl and sufentanil metabolism as opposed to alfentanil

✍ Scribed by Jérôme Guitton; Thierry Buronfosse; Michel Désage; Alain Lepape; Jean-Louis Brazier; Philippe Beaune


Book ID
119407252
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
845 KB
Volume
53
Category
Article
ISSN
0006-2952

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The concept of relative activity factor (RAF) to extrapolate data obtained with recombinant cytochrome P450(CYP)s to human liver microsomes has been proposed. To evaluate the approach to predict the contribution of multiple CYPs using RAF, we investigated the effects of the differences in the expres