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Possible involvement of 1,2-diacetylbenzene in diethylbenzene-induced neuropathy in rats

✍ Scribed by F. Gagnaire; A. Ensminger; B. Marignac; J. de Ceaurriz

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
447 KB
Volume
11
Category
Article
ISSN
0260-437X

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✦ Synopsis

The role of 1,2-diacetyIbenzene (1,2-DAB) in the peripheral nerve toxicity of 1,2-diethyIbenzene (1,2-DEB) was investigated in rats. Gas chromatography-mass spectrometry identified 1,2-DAB in the urine samples of rats given 165 mg kg-' 1,2-DEB orally on four consecutive days. I,2-DAB shared not only the ability of 1,2-DEB to cause bluish discoloration of skin, internal organs and urine, but unlike 1,2-DEB it turned hair blue at the site of intraperitoneal injection.

Intraperitoneal administration of 10 mg kg-l and 20 mg kg-l 1,2-DAB to groups of 12 rats, 4 days a week for 11 and 6 weeks, caused a dose-and time-dependent decrease in mean sensory and motor conduction velocities. Recovery in a 5-week post-exposure period was gradual but consistent. The effect of 1,2-DAB on the amplitude of the sensory action potential was ambiguous.

The findings support the hypothesis that the formation of 1,2-diacetylbenzene derivatives contributes to the neurotoxicity of 1,2-DEB.

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