Possible cyclic AMP-dependence of the prereplicative surge of cytosolic calmodulin in proliferatively activated rat liver cells

The possible cyclic AMP-dependence of an

The possible cyclic AMP-dependence of an early prereplicative event that determines mitosis in regenerating rat liver

✍ R. H. Rixon; J. F. Whitfield 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 656 KB

The beta-adrenergic blocker dl-propranolol prevented a large proportion of regenerating rat liver cells from entering the mitotic phase of their first cell division cycle without affecting their ability to initiate or complete DNA replication. The drug, at a dose of 20 or 50 mg/kg of body weight, wa