Possible contribution of circulating transforming growth factor-β1 to immunity and prognosis in unresectable hepatocellular carcinoma
✍ Scribed by Kazuo Okumoto; Etsuko Hattori; Kazuko Tamura; Shinichi Kiso; Hisayoshi Watanabe; Koji Saito; Takafumi Saito; Hitoshi Togashi; Sumio Kawata
- Book ID
- 111237208
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 159 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0106-9543
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Alteration of transforming growth factor beta1 (TGF-beta1) type II receptor (RII) appears to cause unresponsiveness to TGF-beta1 in tumorigenic cells. Defect in the mononucleotide repeat sequence, i.e., poly A region of TGF-beta1RII gene has been reported to be related to replication error-positive
tumors, which was cancelled by anti-TGF-b 1 antibodies. 13 A patient, having a huge hepatic hemangioma, pre- These findings indicate that the elevated concentration of sented with decreases in the number of peripheral lymcirculating TGF-b 1 may exert an imunosuppression in vivo. phocytes and in ser
## Abstract A change in the balance between proliferation and apoptosis in the course of hepatocellular carcinoma (HCC) development and progression has been suspected. We wanted to identify related genes whose mRNA levels could provide markers of severity and prognosis after resection. The extent o