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Possible changes in gene activity during the ageing of human fibroblasts

โœ Scribed by S.J. Fulder; G.M. Tarrant


Book ID
116137567
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
460 KB
Volume
10
Category
Article
ISSN
0531-5565

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The molecular changes associated with the aging process include the reduced activity of transcription factors (such as AP-1) and an impaired response to stress, which has been well documented in the case of the heatshock (HS) response. Using human diploid fibroblasts of early and late passages as an