Possible bioactive conformations of α-melanotropin
✍ Scribed by G.V. Nikiforovich; S.A. Rozenblit; M.D. Shenderovich; G.I. Chipens
- Book ID
- 115916322
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 417 KB
- Volume
- 170
- Category
- Article
- ISSN
- 0014-5793
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Cyclolinopeptide A, a cyclic nonapeptide, was isolated in 1956 from linseed oil.' In 1966 Prox and Weygand' determined the amino acid composition and they elucidated the sequence of the peptide, demonstrating the following chemical structure: \*Dedicated to the memory of Professor F. Weygand.
## Abstract Chemical synthesis and biological activities of a new α‐melanotropin derivative are described. __N__^α^‐(5‐Bromovaleryl)‐__N__^α^‐deacetyl‐α‐melanotropin contains the 5‐bromopentanoyl group as a chemical ‘handle’ in place of the acetyl group of the natural hormone. The synthesis involve