Possible association of p53 codon 72 polymorphism with susceptibility to adult and pediatric high-grade astrocytomas
โ Scribed by Preeti Parhar; Rona Ezer; Yongzhao Shao; Jeffrey C. Allen; Douglas C. Miller; Elizabeth W. Newcomb
- Book ID
- 116753321
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 125 KB
- Volume
- 137
- Category
- Article
- ISSN
- 0169-328X
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## Background Emerging evidence has shown that __p53__gene participates in human carcinogenesis as tumor suppressors. Polymorphism of __p53__ gene codon 72 Arg/Pro (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis. It has been suggested that __p5
A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occ
## Abstract Human papillomavirus (HPV) infects the squamous epithelial cells of oral cavity and cervix leading to formation of warts that develops into the cancer. Human papillomavirus (HPV)โ16 and 18 encode E6 oncoprotein, which binds to and induces degradation of the tumour suppressor protein p53