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Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population

✍ Scribed by Helisalmi, S.; Dermaut, B.; Hiltunen, M.; Mannermaa, A.; Van den Broeck, M.; Lehtovirta, M.; Koivisto, A. M.; Iivonen, S.; Cruts, M.; Soininen, H.; Van Broeckhoven, C.

Book ID
118053429
Publisher
Lippincott Williams and Wilkins
Year
2004
Tongue
English
Weight
121 KB
Volume
63
Category
Article
ISSN
0028-3878

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## Abstract Granulin protein plays an important role in neurite outgrowth and neuronal survival. Recently, it was shown that mutations in __granulin__ (__GRN__) gene cause tau‐negative frontotemporal dementia supporting the idea that granulin is involved in neurodegeneration. Here we have investiga