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Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder

✍ Scribed by Ryota Hashimoto; Hitoshi Hashimoto; Norihito Shintani; Kazutaka Ohi; Hiroaki Hori; Osamu Saitoh; Asako Kosuga; Masahiko Tatsumi; Nakao Iwata; Norio Ozaki; Kunitoshi Kamijima; Akemichi Baba; Masatoshi Takeda; Hiroshi Kunugi

Book ID: 116771877
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 123 KB
Volume: 468
Category: Article
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2009.11.019

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It has been demonstrated that pituitary adenylate cyclase activating polypeptide (PACAP) promotes the survival of neurons in culture and can inhibit neuronal cell death after experimental injury. Furthermore, peripheral axotomy results in increased PACAP gene expression in sensory and sympathetic ne